Duodenal bacterial overgrowth during treatment in outpatients with omeprazole.

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Duodenal bacterial overgrowth during treatment in outpatients with omeprazole.

The extent of duodenal bacterial overgrowth during the pronounced inhibition of acid secretion that occurs with omeprazole treatment is unknown. The bacterial content of duodenal juice of patients treated with omeprazole was therefore examined in a controlled prospective study. Duodenal juice was obtained under sterile conditions during diagnostic upper endoscopy. Aspirates were plated quantita...

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Bacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomised double blind study.

BACKGROUND Gastric and duodenal bacterial overgrowth frequently occurs in conditions where diminished acid secretion is present. Omeprazole inhibits acid secretion more effectively than cimetidine and might therefore more frequently cause bacterial overgrowth. AIM This controlled prospective study compared the incidence of gastric and duodenal bacterial overgrowth in patients treated with ome...

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Intragastric nitrites, nitrosamines, and bacterial overgrowth during cimetidine treatment.

A six week course of cimetidine (1 g/day) healed peptic ulcers in 20 of 23 patients (14 with duodenal ulcer, nine with gastric ulcer). Reduction of basal acid output by 73% and peak acid output by 36% led to a rise in concentrations of intragastric aerobic bacteria and nitrate-reducing bacteria. While the mean intragastric concentration of nitrate was unchanged by treatment, there were statisti...

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Treatment of Bacterial Overgrowth in Patients With Irritable Bowel Syndrome

Background: Rifaximin is an effective treatment of irritable bowel syndrome (IBS) with small intestinal bacterial overgrowth (SIBO), yet long-term management has not been well studied. Patients with functional bowel symptoms were characterized by lactulose breath test (LBT), and a comprehensive approach to long-term SIBO therapy was employed. Methods: On day 0, eligible patients completed a bas...

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Treatment of small intestine bacterial overgrowth.

Removal of the predisposing condition, appropriate nutritional support to reintegrate both caloric and vitamin requirements and suppression of the contaminating bacterial flora represent the main of goals of the treatment of small intestine bacterial overgrowth. Generally, the polymicrobic nature of contaminating flora requires the administration of wide-spectrum antibiotics, but as yet we don'...

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ژورنال

عنوان ژورنال: Gut

سال: 1994

ISSN: 0017-5749

DOI: 10.1136/gut.35.1.23